Health Medical Homework Help

B cell malignancies refer to a group of blood cancers that are characterized by abnormal B cell numbers and/or phenotypes. B cell leukemias are cancers found in the blood or bone marrow, while B cell lymphomas are cancers localized to secondary lymphoid tissues such as the lymph nodes. These malignancies often result from genetic mutations in pathways involved in B cell development, activation, and regulation, and therefore highlight the importance of properly regulated B cell development and signaling. During Week 5 of Applied Immunology we’ve learned about the mechanisms of B cell development and signaling, which means that you are now equipped with the terminology and conceptual knowledge to research how certain underlying genetic mutations could lead to the uncontrolled proliferation of B cells that form leukemias and lymphomas.

For this week’s discussion board, please pick a form of B cell malignancy and present a summary of this cancer which addresses the following questions:

1. 1. 1. Which target gene is mutated in this B cell malignancy? Is it known how this mutation is inherited? If there are several genetic drivers proposed for this malignancy, pick one to explain in your summary.
      2. Which pathways in B cell development, signaling, or activation are involved? Is it known which type of B cell (or stage in B cell development) is the cell of origin for this type of cancer? Again, if there are several potential targets, discuss those that are related to the genetic mutation that you chose for question #1.
      3. What are the clinical symptoms of this B cell malignancy? What is the survival prognosis of these cancer patients?
      4. Are there any known treatments?

You can either pick a specific B cell malignancy that interests you after doing some of your own research, or select from this list of examples:

1. 1. 1. Diffuse large B cell lymphoma (DLBCL; a type of non-Hodgkin lymphoma)
      2. Hodgkin lymphomas
      3. Follicular lymphoma
      4. Chronic lymphocytic leukemia (CLL)
      5. B cell acute lymphoblastic leukemia (B cell ALL)
      6. Mantle cell lymphoma (MCL)
      7. Burkitt lymphoma
      8. Hairy cell leukemia

You should be able to present a summary of your chosen B cell malignancy within 2-3 written paragraphs (not formatted as bullet points). Responses must be written in your own words. As with previous discussion prompts for this course, please include citations for the sources that you used to learn about your chosen SCID at the end of your response (you may use any citation format that you prefer). Again, please keep in mind that there are 3 categories of scientific literature sources: (1) primary research articles, which are written by scientists and report their original experimental findings, (2) secondary research articles, which are review articles written by scientists that typically present a summary of a given topic without original experimental results, and (3) tertiary articles, which include pieces published in the popular media. Tertiary news sources represent venues of scientific communication that are more susceptible to influence by external social and cultural factors that may affect an article’s objectivity, which can impact the quality and reliability of information that is presented. From a scientific standpoint, it is best to read about your topic of interest using primary and secondary research articles published by established journals, as these articles have been subjected to a scientific quality control process called peer review. You are strongly encouraged to find and read scientific literature on your selected PID that has been published in a reputable scientific journal using search engines such as PubMed (https://pubmed.ncbi.nlm.nih.gov (Links to an external site.)). If you have issues with additional journal access through your university and must include tertiary sources of information for this assignment, please include a short sentence with your citation that communicates why you trust that source of scientific information.

To help you get started, I’ve attached some secondary scientific review articles here which discuss different B cell malignancies. You don’t have to read all of them, just pick a blood cancer that you’re interested in learning more about. You can skim through these review articles to help you decide which leukemia or lymphoma to cover for this assignment, and you can also use these articles for citations if you find relevant information that helps you write your summary.

B Cell Malignancies.pdf

Acute Lymphoblastic Leukemia (ALL).pdf download

B Cell ALL.pdf download

Burkitt Lymphoma.pdf download

Chronic Lymphocytic Leukemia (CLL).pdf download

Diffuse Large B Cell Lymphoma (DLBCL).pdf download

Follicular Lymphoma.pdf download

Hairy Cell Leukemia.pdf download

Therapies for B Cell Lymphomas.pdf