Chemistry homework help

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PH 604                                                                                                                  NAME                                                                  
Homework 2                                                                                                      RED ID____________________________
 
 
The purpose of this assignment is to better understand the toxicity and exposure of certain chemicals. You will learn to collect important chemical information commonly used in EH.
 
Please write your answers in the document. After completing this homework, please save the document with the following name: HW2_YOUR Last Name_Date and then upload it to CANVAS.
 

  1. Health Effect (1 points):

 
 
Leukemia
Lung cancer
Skin cancera
Breast cancer
Intestinal cancer
Low birth weight
Preterm birth
Developmental effects – heart
Developmental effects – neurological
Low or absent sperm count
Other male reproductive toxicity
Autism
Birth defects (various)
Asthma
Wheeze
Type II diabetes
Hormonal alterations
Estrogenic effects
Kidney toxicity
Liver toxicity
Cataracts
Dermatitis
Skin conditions general
Chloracne (skin)
Immune system toxicity
Sensitization
Parkinsonism
Peripheral neurotoxicity
Neurological toxicity – other
Cholinesterase inhibition effects
Obesity
Heart attacks
Cardiotoxic effects
 
(other, write in with permission of instructor)
 
 
Please pick ONE health effect from the list below and write it here:_____________________________________________________________
 
1) List THREE chemicals (CAN BE A MIXTURE in some cases, such as tobacco smoke) that are associated with your particular health effect:THESE HAVE TO BE ENVIRONMENTAL CHEMICALS, NOT PHARMACEUTICALS (meaning something like arsenic, not a medicine like Prozac). Put chemical or mixture name, and CAS or RN for the chemical. Go to pubchemhttps://pubchem.ncbi.nlm.nih.gov/( 0.5 points each of the three below)
 
1.1.Chemical Name______________________________________________________
CAS or RN number __________________________________________________
 
1.2. Chemical Name _________________________________________________________
CAS or RN number __________________________________________________
 
1.3. Chemical Name _________________________________________________________
CAS or RN number __________________________________________________
 
2)Of the THREEchemicals you selected above, chooseONEand answer the following questions, using resources on pubchemhttps://pubchem.ncbi.nlm.nih.gov/as well as ATSDR Tox guides , if any https://www.atsdr.cdc.gov/toxguides/index.asp#B  and Tox Profiles https://www.atsdr.cdc.gov/toxprofiledocs/index.html
2.1 Selected chemical/ CAS #(0.5 points) ______________________________________________
Other names (no more than 3 here) ____________________________________
2.2 Of the ONEchemical selected, what is the Octanol-Water partition coefficient (log Kow) and if available, what is the Octanol-Air partition coefficient (LogKoa)? (0.5 points)
LogKow =
LogKoa =
2.3What are the main uses for this chemical? (0.5 point)
 
3)Why and how are people exposed? What are the main exposure routes?(0.5 points)
 
3.1If chemical is not in use today, is it still persistent in environment? (0.5 points)
 
3.2Is there significant exposure in the workplace or community/environment or both?(0.5 points)
 
4)Please list any health EFFECTS of CHRONIC exposure to this chemical  here  – UNLESS you are in the UNUSUAL situation of your chemical presenting an ACUTE health effect (explain) (usually chronic exposures are the issue in environmental health, but not always  – for example, carbon monoxide presents an acute health hazard(1 point)
 
4.1 As you may noticed, some chemicals have a lot information regarding their toxicity, based on the information you obtained, is this chemical a carcinogenic or teratogenic or mutagenic or a combination or none? (0.5 points)
 
4.1 What are the most common target organsonce this chemical is inside the body (shortly mention where it is distributed/accumulates) ? (1 point)
 
4.2 What is the LD50 of the selected chemical? Please note that some chemicals may have more than one LD50, depending on the organism (rats, mice, guinea pigs, rabbits, etc) or if it was injected, inhaled, ingested, dermal, etc. If more than one LD50 is found, please DO NOT list more than FIVE if more than one is available (1 point).
Homework2Instructions-1