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What Else Is Commonly Observed in Human Cancers Have Defective P53 Question

I’m working on a biology question and need an explanation to help me understand better.

Approximately half of all human cancers have defective p53. In these cancers, what else is commonly be observed?

Group of answer choices

Decreased p21 expression and decreased DNA mutations.

Increased p21 expression and decreased DNA mutations.

Decreased p21 expression and increased DNA mutations.

Increased p21 expression and increased DNA mutations.