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What Combination Is Most Likely to Cause Cancer Cell Biology Question

 

I’m working on a biology question and need an explanation to help me study.

What combination is most likely to cause cancer?

Loss of all cellular Myc and loss of all cellular Ras.

Loss of all cellular Myc and gain of function for p21.

Loss of all cellular Myc and loss of all cellular p53.

Loss of all cellular Myc and gain of function for Arf.